MicroRNAs in angiogenesis

@article{Bot2012MicroRNAsIA,
  title={MicroRNAs in angiogenesis},
  author={Nathalie Le Bot},
  journal={Nature Cell Biology},
  year={2012},
  volume={14},
  pages={342-342}
}
  • N. Bot
  • Published 1 April 2012
  • Biology
  • Nature Cell Biology
During sprouting angiogenesis, vascular endothelial growth factor (VEGF) activates filopodia formation and the directional migration of an endothelial cell, the tip cell, which takes the lead in forming the new vessel. The tip cell takes with it endothelial trailing stalk cells, which do not make filopodia and form the core of the new vessels. This process also requires inhibition of tip cell behaviour in stalk cells through crosstalk between VEGF and Notch signalling. Lawson and colleagues… 

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