MicroRNAs in Human Placental Development and Pregnancy Complications

  title={MicroRNAs in Human Placental Development and Pregnancy Complications},
  author={Guodong Fu and Jelena Brki{\'c} and Heyam Hayder and Chun Peng},
  booktitle={International journal of molecular sciences},
MicroRNAs (miRNAs) are small non-coding RNAs, which function as critical posttranscriptional regulators of gene expression by promoting mRNA degradation and translational inhibition. Placenta expresses many ubiquitous as well as specific miRNAs. These miRNAs regulate trophoblast cell differentiation, proliferation, apoptosis, invasion/migration, and angiogenesis, suggesting that miRNAs play important roles during placental development. Aberrant miRNAs expression has been linked to pregnancy… CONTINUE READING
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