MicroRNAs from peripheral blood mononuclear cells as biomarkers for detection of preclinical fibrosarcoma

Abstract

Background Blood immune cells cooperate to prevent the progression of tumors through cancer immunosurveillance. Since activated peripheral immune cell clones trigger a sensitive transcriptional response upon recognition of tumors, which can be identified by transcriptional profiling, we hypothesised that peripheral blood mononuclear cells (PBMCs) could be… (More)

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