MicroRNAs distinguish translational from transcriptional silencing during endotoxin tolerance.

@article{Gazzar2010MicroRNAsDT,
  title={MicroRNAs distinguish translational from transcriptional silencing during endotoxin tolerance.},
  author={Mohamed El Gazzar and Charles E McCall},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 27},
  pages={20940-51}
}
We reported that gene-selective formation of facultative heterochromatin silences transcription of acute inflammatory genes during endotoxin (LPS) tolerance, according to function. We discovered that reversal of the epigenetically silenced transcription restored mRNA levels but not protein synthesis. Here, we find that translation repression of tumor necrosis factor-alpha (TNFalpha) occurs independent of transcription silencing during LPS tolerance. The process required to disrupt protein… CONTINUE READING

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