MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma

  title={MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma},
  author={Aaron L. Sarver and Venugopal Thayanithy and Milcah C Scott and Anne-Marie Cleton-Jansen and Pancras C. W. Hogendoorn and Jaime F Modiano and Subbaya Subramanian},
  booktitle={Orphanet journal of rare diseases},
BACKGROUND Deregulation of microRNA (miRNA) transcript levels has been observed in many types of tumors including osteosarcoma. Molecular pathways regulated by differentially expressed miRNAs may contribute to the heterogeneous tumor behaviors observed in naturally occurring cancers. Thus, tumor-associated miRNA expression may provide informative biomarkers for disease outcome and metastatic potential in osteosarcoma patients. We showed previously that clusters of miRNAs at the 14q32 locus are… CONTINUE READING
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