MicroRNAs as regulators of epithelial-mesenchymal transition.

  title={MicroRNAs as regulators of epithelial-mesenchymal transition.},
  author={Philip A Gregory and Cameron P. Bracken and Andrew G. Bert and Gregory J. Goodall},
  journal={Cell cycle},
  volume={7 20},
Epithelial-mesenchymal transition (EMT) describes the molecular reprogramming and phenotypic changes involved in the conversion of polarised immotile epithelial cells to motile mesenchymal cells. This process allows the remodelling of tissues during embryonic development and is implicated in the promotion of tumor invasion and metastasis. Several recent studies have identified the miR-200 family and miR-205 as key regulators of EMT and enforcers of the epithelial phenotype. The miR-200 family… CONTINUE READING
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