MicroRNAs as novel therapeutic targets to treat kidney injury and fibrosis.

  title={MicroRNAs as novel therapeutic targets to treat kidney injury and fibrosis.},
  author={Ivan G. Gomez and Naoki Nakagawa and Jeremy S. Duffield},
  journal={American journal of physiology. Renal physiology},
  volume={310 10},
MicroRNAs (miRs), a class of small noncoding RNAs that act as post-transcriptional regulators of gene expression, have attracted increasing attention as critical regulators of organogenesis, cancer, and disease. Interest has been spurred by development of a novel class of synthetic RNA oligonucleotides with excellent drug-like properties that hybridize to a specific miR, preventing its action. In kidney disease, a small number of miRs are dysregulated. These overlap with regulated miRs in… CONTINUE READING
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