MicroRNAs as a selective channel of communication between competing RNAs: a steady-state theory.

@article{Figliuzzi2013MicroRNAsAA,
  title={MicroRNAs as a selective channel of communication between competing RNAs: a steady-state theory.},
  author={Matteo Figliuzzi and Enzo Marinari and Andrea De Martino},
  journal={Biophysical journal},
  year={2013},
  volume={104 5},
  pages={1203-13}
}
It has recently been suggested that the competition for a finite pool of microRNAs (miRNA) gives rise to effective interactions among their common targets (competing endogenous RNAs or ceRNAs) that could prove to be crucial for posttranscriptional regulation. We have studied a minimal model of posttranscriptional regulation where the emergence and the nature of such interactions can be characterized in detail at steady state. Sensitivity analysis shows that binding free energies and repression… CONTINUE READING

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