MicroRNAs are significantly influenced by p53 and radiation in HCT116 human colon carcinoma cells.

@article{Shin2009MicroRNAsAS,
  title={MicroRNAs are significantly influenced by p53 and radiation in HCT116 human colon carcinoma cells.},
  author={Sangsu Shin and Hwa Jun Cha and Eun-Mee Lee and Jin Hyuk Jung and Su-Jae Lee and I. -S. Park and Young-Woo Jin and Sungkwan An},
  journal={International journal of oncology},
  year={2009},
  volume={34 6},
  pages={1645-52}
}
Ionizing radiation is genotoxic to the cell, and p53 is commonly considered to be a key regulator that controls gene expression responding to the genotoxity of radiation. The expression profiles of microRNAs (miRNAs), which are small non-coding RNAs regulating the translation of target mRNAs, were analyzed to determine whether any correlation exists between miRNA expression, radiation response, and/or p53. The miRNA profiles were analyzed by microarray containing 470 human miRNA probes in… CONTINUE READING