MicroRNAs and their roles in mammalian stem cells.

  title={MicroRNAs and their roles in mammalian stem cells.},
  author={Rui Yi and Elaine Fuchs},
  journal={Journal of cell science},
  volume={124 Pt 11},
Discovered in Caenorhabditis elegans in 1993, microRNAs (miRNAs) make up a novel class of tiny, ~21-24 nucleotide, non-coding RNA species. Since its identification as a key component of a broadly conserved mechanism that regulates gene expression post-transcriptionally, the miRNA pathway has emerged as one of the most extensively investigated pathways of the past decade. Because of their potential to regulate a large number of protein-encoding genes, miRNAs have been implicated in numerous… CONTINUE READING


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