MicroRNAs and their roles in developmental canalization.

  title={MicroRNAs and their roles in developmental canalization.},
  author={Diana M. Posadas and Richard W. Carthew},
  journal={Current opinion in genetics & development},
Robustness is a fundamental property of biological systems. The type of robustness that ensures uniform phenotypic outcomes in the face of variation during an organism's development is called canalization. Here, we discuss the roles that microRNAs play in providing canalization to animal development, citing recent theoretical and experimental advances. MicroRNAs repress protein expression, and they do this in ways that create thresholds in expression and provide adaptation to regulatory… CONTINUE READING
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