MicroRNAs and their isomiRs function cooperatively to target common biological pathways

@inproceedings{Cloonan2011MicroRNAsAT,
  title={MicroRNAs and their isomiRs function cooperatively to target common biological pathways},
  author={Nicole Cloonan and Shivangi Wani and Qinying Xu and Jian Hua Gu and Kristi Lea and Sheila Heater and Catalin Barbacioru and Anita L Steptoe and Hilary C Martin and Ehsan Nourbakhsh and Keerthana Krishnan and Brooke B A Gardiner and Xiaohui Wang and Katia Nones and Jason A. Steen and Nicholas A Matigian and David L. A. Wood and Karin S. Kassahn and Nicola Waddell and Jill L Shepherd and Clarence S. C. Lee and Jeff Ichikawa and Kevin Mckernan and Kelli Bramlett and Scott Kuersten and Sean M. Grimmond},
  booktitle={Genome Biology},
  year={2011}
}
Variants of microRNAs (miRNAs), called isomiRs, are commonly reported in deep-sequencing studies; however, the functional significance of these variants remains controversial. Observational studies show that isomiR patterns are non-random, hinting that these molecules could be regulated and therefore functional, although no conclusive biological role has been demonstrated for these molecules. To assess the biological relevance of isomiRs, we have performed ultra-deep miRNA-seq on ten adult… CONTINUE READING
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