MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms.

@article{Zeng2003MicroRNAsAS,
  title={MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms.},
  author={Yan Zeng and Rui Yi and Bryan R Cullen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 17},
  pages={9779-84}
}
MicroRNAs (miRNAs) are endogenously encoded small noncoding RNAs, derived by processing of short RNA hairpins, that can inhibit the translation of mRNAs bearing partially complementary target sequences. In contrast, small interfering RNAs (siRNAs), which are derived by processing of long double-stranded RNAs and are often of exogenous origin, degrade mRNAs bearing fully complementary sequences. Here, we demonstrate that an endogenously encoded human miRNA is able to cleave an mRNA bearing fully… CONTINUE READING
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