MicroRNAs activate gene transcription epigenetically as an enhancer trigger

  title={MicroRNAs activate gene transcription epigenetically as an enhancer trigger},
  author={Min Xiao and Jin Li and Wei Li and Yu Dan Wang and Feizhen Wu and Yanping Xi and Lan Zhang and Chao Ding and Huaibing Luo and Yan Xiu Li and Lina Peng and Liping Zhao and Shaoliang Peng and Yao Xiao and Shihua Dong and Jie Cao and Wenqiang Yu},
  booktitle={RNA biology},
MicroRNAs (miRNAs) are small non-coding RNAs that function as negative gene expression regulators. Emerging evidence shows that, except for function in the cytoplasm, miRNAs are also present in the nucleus. However, the functional significance of nuclear miRNAs remains largely undetermined. By screening miRNA database, we have identified a subset of miRNA that functions as enhancer regulators. Here, we found a set of miRNAs show gene-activation function. We focused on miR-24-1 and found that… CONTINUE READING
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