MicroRNAs accurately identify cancer tissue origin

  title={MicroRNAs accurately identify cancer tissue origin},
  author={Nitzan Rosenfeld and Ranit Aharonov and Eti Meiri and Shai Rosenwald and Yael Spector and Merav Zepeniuk and Hila Benjamin and Norberto Shabes and Sarit Tabak and Asaf Levy and Danit Lebanony and Yaron J. Goren and Erez Silberschein and Nurit Targan and Alex Ben-Ari and Shlomit Gilad and Netta Sion-Vardy and Ana Tobar and Meora Feinmesser and Oleg Kharenko and Ofer Nativ and D Nass and Marina Perelman and Ady Yosepovich and Bruria Shalmon and Sylvie Polak-Charcon and Eddie Fridman and Amir Avniel and Isaac Bentwich and Zvi Bentwich and Dalia Cohen and Ayelet Chajut and Iris Barshack},
  journal={Nature Biotechnology},
MicroRNAs (miRNAs) belong to a class of noncoding, regulatory RNAs that is involved in oncogenesis and shows remarkable tissue specificity. Their potential for tumor classification suggests they may be used in identifying the tissue in which cancers of unknown primary origin arose, a major clinical problem. We measured miRNA expression levels in 400 paraffin-embedded and fresh-frozen samples from 22 different tumor tissues and metastases. We used miRNA microarray data of 253 samples to… CONTINUE READING

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