MicroRNAs Modulate Hematopoietic Lineage Differentiation

@article{Chen2004MicroRNAsMH,
  title={MicroRNAs Modulate Hematopoietic Lineage Differentiation},
  author={Chang-zheng Chen and L. Li and H. Lodish and D. Bartel},
  journal={Science},
  year={2004},
  volume={303},
  pages={83 - 86}
}
  • Chang-zheng Chen, L. Li, +1 author D. Bartel
  • Published 2004
  • Medicine, Biology
  • Science
  • MicroRNAs (miRNAs) are an abundant class of ∼22-nucleotide regulatory RNAs found in plants and animals. Some miRNAs of plants, Caenorhabditis elegans, and Drosophila play important gene-regulatory roles during development by pairing to target mRNAs to specify posttranscriptional repression of these messages. We identify three miRNAs that are specifically expressed in hematopoietic cells and show that their expression is dynamically regulated during early hematopoiesis and lineage commitment… CONTINUE READING

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