MicroRNAs MiR-17, MiR-20a, and MiR-106b Act in Concert to Modulate E2F Activity on Cell Cycle Arrest during Neuronal Lineage Differentiation of USSC

@inproceedings{Trompeter2011MicroRNAsMM,
  title={MicroRNAs MiR-17, MiR-20a, and MiR-106b Act in Concert to Modulate E2F Activity on Cell Cycle Arrest during Neuronal Lineage Differentiation of USSC},
  author={Hans-Ingo Trompeter and Hassane Abbad and Katharina M. Iwaniuk and Markus Hafner and Neil Renwick and Thomas Tuschl and Jessica Schira and Hans Werner M{\"u}ller and Peter Wernet},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND MicroRNAs are short (∼22 nt) non-coding regulatory RNAs that control gene expression at the post-transcriptional level. Here the functional impact of microRNAs on cell cycle arrest during neuronal lineage differentiation of unrestricted somatic stem cells from human cord blood (USSC) was analyzed. METHODOLOGY/PRINCIPAL FINDINGS Expression profiling revealed downregulation of microRNAs miR-17, -20a, and -106b in USSC differentiated into neuronal lineage but not in USSC… CONTINUE READING
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