MicroRNAs Inhibit the Translation of Target mRNAs on the Endoplasmic Reticulum in Arabidopsis

@article{Li2013MicroRNAsIT,
  title={MicroRNAs Inhibit the Translation of Target mRNAs on the Endoplasmic Reticulum in Arabidopsis},
  author={Shengben Li and Lin L. Liu and Xiaohong Zhuang and Yu Yu and Xigang Liu and Xia Cui and Lijuan Ji and Zhiqiang Pan and Xiaofeng Cao and Beixin Mo and Fuchun Zhang and Natasha V. Raikhel and Liwen Jiang and Xuemei Chen},
  journal={Cell},
  year={2013},
  volume={153},
  pages={562-574}
}
Translation inhibition is a major but poorly understood mode of action of microRNAs (miRNAs) in plants and animals. In particular, the subcellular location where this process takes place is unknown. Here, we show that the translation inhibition, but not the mRNA cleavage activity, of Arabidopsis miRNAs requires ALTERED MERISTEM PROGRAM1 (AMP1). AMP1 encodes an integral membrane protein associated with endoplasmic reticulum (ER) and ARGONAUTE1, the miRNA effector and a peripheral ER membrane… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS