MicroRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos.

  title={MicroRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos.},
  author={Dionna Kasper and Albertomaria Moro and Emma Ristori and Anand Narayanan and Guillermina Hill-Teran and Elizabeth S. Fleming and Miguel A. Moreno-Mateos and Charles E. Vejnar and Jing Maria Zhang and Donghoon Lee and Mengting Gu and Mark B Gerstein and Antonio J Giraldez and Stefania Nicoli},
  journal={Developmental cell},
  volume={40 6},
Proper functioning of an organism requires cells and tissues to behave in uniform, well-organized ways. How this optimum of phenotypes is achieved during the development of vertebrates is unclear. Here, we carried out a multi-faceted and single-cell resolution screen of zebrafish embryonic blood vessels upon mutagenesis of single and multi-gene microRNA (miRNA) families. We found that embryos lacking particular miRNA-dependent signaling pathways develop a vascular trait similar to wild-type… CONTINUE READING
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