MicroRNAs Distinguish Cytogenetic Subgroups in Pediatric AML and Contribute to Complex Regulatory Networks in AML-Relevant Pathways

@inproceedings{Daschkey2013MicroRNAsDC,
  title={MicroRNAs Distinguish Cytogenetic Subgroups in Pediatric AML and Contribute to Complex Regulatory Networks in AML-Relevant Pathways},
  author={Svenja Daschkey and Silja Roettgers and Anamika Giri and Jutta Bradtke and Andrea Teigler-Schlegel and Gunter Meister and Arndt Borkhardt and Pablo Landgraf},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND The role of microRNAs (miRNAs), important post-transcriptional regulators, in the pathogenesis of acute myeloid leukemia (AML) is just emerging and has been mainly studied in adults. First studies in children investigate single selected miRNAs, however, a comprehensive overview of miRNA expression and function in children and young adults is missing so far. METHODOLOGY/PRINCIPAL FINDINGS We here globally identified differentially expressed miRNAs between AML subtypes in a survey of… CONTINUE READING

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