MicroRNAs 15a/16-1 function as tumor suppressor genes in multiple myeloma.

@article{Gatt2010MicroRNAs1F,
  title={MicroRNAs 15a/16-1 function as tumor suppressor genes in multiple myeloma.},
  author={Moshe E Gatt and Jian-jun Zhao and Margaret S. Ebert and Yunyu Zhang and Zhangbo Chu and Mala Mani and Roi Gazit and Daniel E. Carrasco and Jui Dutta-Simmons and Sophia Adamia and St{\'e}phane Minvielle and Yu-Tzu Tai and Nikhil C. Munshi and Herv{\'e} Avet-Loiseau and Kenneth C. Anderson and Daniel Ruben Carrasco},
  journal={Blood},
  year={2010}
}
Multiple myeloma is characterized by frequent chromosomal alterations. Deletion of chr 13, especially band 13q14, is commonly observed in early stages of MM, suggesting the presence of tumor suppressor genes within this region. Here, we functionally validate the role of the microRNAs-15a/16-1 cluster, centered at the deleted region, as TSGs and delineate… CONTINUE READING