MicroRNAs — the micro steering wheel of tumour metastases

  title={MicroRNAs — the micro steering wheel of tumour metastases},
  author={Milena Sabrina Nicoloso and Riccardo Spizzo and Masayoshi Shimizu and Simona Rossi and George A. Calin},
  journal={Nature Reviews Cancer},
Recently, microRNAs (miRNAs) have been discovered to have a role in metastasis. Here we describe how miRNAs are involved in advanced stages of tumour progression, stressing their roles as metastasis activators or suppressors, and discuss their possible use in the clinic as predictive markers and as therapeutic strategies for patients with metastases. Furthermore, we develop the concept that the same miRNAs could be involved both in the cancer stem cell phenotype and in the ability of specific… CONTINUE READING

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