MicroRNAs, wild-type and mutant p53: more questions than answers.

  title={MicroRNAs, wild-type and mutant p53: more questions than answers.},
  author={Matthew F. Jones and Ashish Nandan Lal},
  journal={RNA biology},
  volume={9 6},
The tumor suppressor p53 is a sequence-specific transcription factor that activates the expression of genes involved in apoptosis, cell cycle arrest and senescence. p53 can also inhibit gene expression and this effect is partly mediated by inducing several microRNAs (miRNAs). MiRNAs have emerged as a new class of regulators of the expression and function of eukaryotic genomes. Tumor suppressive or oncogenic functions have been attributed to some miRNAs. Recent studies have shown that p53 can… CONTINUE READING
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