MicroRNA-target pairs in the rat kidney identified by microRNA microarray, proteomic, and bioinformatic analysis.

@article{Tian2008MicroRNAtargetPI,
  title={MicroRNA-target pairs in the rat kidney identified by microRNA microarray, proteomic, and bioinformatic analysis.},
  author={Zhongmin Tian and Andrew S. Greene and Jennifer L Pietrusz and Isaac R. Matus and Mingyu Liang},
  journal={Genome research},
  year={2008},
  volume={18 3},
  pages={359-69}
}
Mammalian genomes contain several hundred highly conserved genes encoding microRNAs. In silico analysis has predicted that a typical microRNA may regulate the expression of hundreds of target genes, suggesting miRNAs might have broad biological significance. A major challenge is to obtain experimental evidence for predicted microRNA-target pairs. We reasoned that reciprocal expression of a microRNA and a predicted target within a physiological context would support the presence and relevance of… CONTINUE READING