MicroRNA-specific regulatory mechanisms in atherosclerosis.

  title={MicroRNA-specific regulatory mechanisms in atherosclerosis.},
  author={Maliheh Nazari-Jahantigh and Virginia Egea and Andreas Schober and Christian Weber},
  journal={Journal of molecular and cellular cardiology},
  volume={89 Pt A},
During the past decade, the crucial role of microRNAs (miRs) controlling tissue homeostasis and disease in the cardiovascular system has become widely recognized. By controlling the expression levels of their targets, several miRs have been shown to modulate the function of endothelial cells, vascular smooth muscle cells, and macrophages, thereby regulating the development and progression of atherosclerosis. For instance, miR-155 can exacerbate early stages of atherosclerosis by increasing the… CONTINUE READING