MicroRNA signatures in human cancers

@article{Calin2006MicroRNASI,
  title={MicroRNA signatures in human cancers},
  author={George Adrian Calin and Carlo Maria Croce},
  journal={Nature Reviews Cancer},
  year={2006},
  volume={6},
  pages={857-866}
}
MicroRNA (miRNA) alterations are involved in the initiation and progression of human cancer. The causes of the widespread differential expression of miRNA genes in malignant compared with normal cells can be explained by the location of these genes in cancer-associated genomic regions, by epigenetic mechanisms and by alterations in the miRNA processing machinery. MiRNA-expression profiling of human tumours has identified signatures associated with diagnosis, staging, progression, prognosis and… 
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The role of miRNAs in the pathogenesis of cancer as well as miRNA-profiling studies performed in human malignancies are examined, and implications for the diagnosis and treatment of cancer patients are discussed.
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