MicroRNA signature predicts survival and relapse in lung cancer.

  title={MicroRNA signature predicts survival and relapse in lung cancer.},
  author={Sung-Liang Yu and Hsuan-Yu Chen and G. -t. Chang and Chih-Yi Chen and H. W. Chen and Sher Singh and Chiou-Ling Cheng and Chong-Jen Yu and Y Lee and H. S. Chen and Te-Jen Su and Ching-Cheng Chiang and H Li and Q Hong and Hsin-Yuan Su and Chun-Chieh Chen and Wan-Jiun Chen and C Liu and Wing-Kai Chan and Wei jun Chen and K C Li and Jeremy J. W. Chen and Pan-Chyr Yang},
  journal={Cancer cell},
  volume={13 1},
We investigated whether microRNA expression profiles can predict clinical outcome of NSCLC patients. Using real-time RT-PCR, we obtained microRNA expressions in 112 NSCLC patients, which were divided into the training and testing sets. Using Cox regression and risk-score analysis, we identified a five-microRNA signature for the prediction of treatment outcome of NSCLC in the training set. This microRNA signature was validated by the testing set and an independent cohort. Patients with high-risk… CONTINUE READING
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