MicroRNA profiling of human primary macrophages exposed to dengue virus identifies miRNA-3614-5p as antiviral and regulator of ADAR1 expression

@inproceedings{DiosaToro2017MicroRNAPO,
  title={MicroRNA profiling of human primary macrophages exposed to dengue virus identifies miRNA-3614-5p as antiviral and regulator of ADAR1 expression},
  author={Mayra Diosa-Toro and Liliana Echavarr{\'i}a-Consuegra and Jacky Flipse and Geysson Javier Fern{\'a}ndez and Joost Kluiver and Anke van den Berg and Silvio Urcuqui-Inchima and Jolanda M. Smit},
  booktitle={PLoS neglected tropical diseases},
  year={2017}
}
BACKGROUND Due to the high burden of dengue disease worldwide, a better understanding of the interactions between dengue virus (DENV) and its human host cells is of the utmost importance. Although microRNAs modulate the outcome of several viral infections, their contribution to DENV replication is poorly understood. METHODS AND PRINCIPAL FINDINGS We investigated the microRNA expression profile of primary human macrophages challenged with DENV and deciphered the contribution of microRNAs to… CONTINUE READING
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