MicroRNA profile of circulating CD4-positive regulatory T cells in human adults and impact of differentially expressed microRNAs on expression of two genes essential to their function.

@article{FayyadKazan2012MicroRNAPO,
  title={MicroRNA profile of circulating CD4-positive regulatory T cells in human adults and impact of differentially expressed microRNAs on expression of two genes essential to their function.},
  author={Hussein Fayyad-Kazan and R{\'e}douane Rouas and Mohammad Fayyad-Kazan and Rabih Badran and Nabil el Zein and Philippe Lewalle and Mehdi Najar and Eva Hamade and Fadi Jebbawi and Makram Merimi and Pedro Romero and Ars{\`e}ne Burny and Bassam M Badran and Philippe Martiat},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 13},
  pages={
          9910-22
        }
}
Regulatory T cells (Tregs) are characterized by a high expression of IL-2 receptor α chain (CD25) and of forkhead box P3 (FOXP3), the latter being essential for their development and function. Another major player in the regulatory function is the cytotoxic T-lymphocyte associated molecule-4 (CTLA-4) that inhibits cytotoxic responses. However, the regulation of CTLA-4 expression remains less well explored. We therefore studied the microRNA signature of circulating CD4(+) Tregs isolated from… CONTINUE READING
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