MicroRNA miR-27 Inhibits Adenovirus Infection by Suppressing the Expression of SNAP25 and TXN2.

@article{Machitani2017MicroRNAMI,
  title={MicroRNA miR-27 Inhibits Adenovirus Infection by Suppressing the Expression of SNAP25 and TXN2.},
  author={Mitsuhiro Machitani and Fuminori Sakurai and Keisaku Wakabayashi and Kosuke Nakatani and Masashi Tachibana and Hiroyuki Mizuguchi},
  journal={Journal of virology},
  year={2017},
  volume={91 12}
}
Recent studies have reported that host microRNAs (miRNAs) regulate infections by several types of viruses via various mechanisms and that inhibition of the miRNA processing factors enhances or prevents viral infection. However, it has not been clarified whether these effects of miRNAs extend to adenovirus (Ad) infection. Here we show that miR-27a and -b efficiently inhibit infection with an Ad via the downregulation of SNAP25 and TXN2, which are members of the SNARE proteins and the thioredoxin… CONTINUE READING