MicroRNA miR-133 represses HERG K+ channel expression contributing to QT prolongation in diabetic hearts.

@article{Xiao2007MicroRNAMR,
  title={MicroRNA miR-133 represses HERG K+ channel expression contributing to QT prolongation in diabetic hearts.},
  author={Jiening Xiao and Xiaobin Luo and Huixian Lin and Ying Zhang and Yanjie Lu and Ning Wang and Yiqiang Zhang and Baofeng Yang and Zhiguo Wang},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={286 32},
  pages={
          28656
        }
}
Abstract We have previously found that the ether-a-go-go related gene (ERG), a long QT syndrome gene encoding a key K+ channel (IKr) in cardiac cells, is severely depressed in its expression at the protein level but not at the mRNA level in diabetic subjects. The mechanisms underlying the disparate alterations of ERG protein and mRNA, however, remained unknown. We report here a remarkable overexpression of miR-133 in hearts from a rabbit model of diabetes, and in parallel the expression of… CONTINUE READING