MicroRNA-mediated repression of nonsense mRNAs

@inproceedings{Zhao2014MicroRNAmediatedRO,
  title={MicroRNA-mediated repression of nonsense mRNAs},
  author={Ya Zhao and Jimin Lin and Beiying Xu and Sida Hu and Xue Zhang and Ligang Wu},
  booktitle={eLife},
  year={2014}
}
Numerous studies have established important roles for microRNAs (miRNAs) in regulating gene expression. Here, we report that miRNAs also serve as a surveillance system to repress the expression of nonsense mRNAs that may produce harmful truncated proteins. Upon recognition of the premature termination codon by the translating ribosome, the downstream portion of the coding region of an mRNA is redefined as part of the 3' untranslated region; as a result, the miRNA-responsive elements embedded in… CONTINUE READING
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