MicroRNA-mediated regulation of T helper cell differentiation and plasticity

  title={MicroRNA-mediated regulation of T helper cell differentiation and plasticity},
  author={Dirk Baumjohann and K Mark Ansel},
  journal={Nature Reviews Immunology},
CD4+ T helper (TH) cells regulate appropriate cellular and humoral immune responses to a wide range of pathogens and are central to the success of vaccines. However, their dysregulation can cause allergies and autoimmune diseases. The CD4+ T cell population is characterized not only by a range of distinct cell subsets, such as TH1, TH2 and TH17 cells, regulatory T cells and T follicular helper cells — each with specific functions and gene expression programmes — but also by plasticity between… CONTINUE READING

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