MicroRNA-mediated deadenylation in a mammalian cell-free system.

MicroRNAs (miRNAs) are 21-22 nucleotide small noncoding RNAs that regulate gene expression posttranscriptionally. The miRNA is incorporated into the miRNP effector complex. The miRNP complex binds to the mRNA containing the target sites, which are partially homologous to the miRNA sequence, and represses protein synthesis. One of the critical functions of… CONTINUE READING