MicroRNA-mediated conversion of human fibroblasts to neurons

@article{Yoo2011MicroRNAmediatedCO,
  title={MicroRNA-mediated conversion of human fibroblasts to neurons},
  author={Andrew S. Yoo and Alfred X. Sun and Li Li and Aleksandr Shcheglovitov and Thomas Portmann and Yulong Li and Chris Lee-Messer and Ricardo E Dolmetsch and Richard W. Tsien and Gerald R Crabtree},
  journal={Nature},
  year={2011},
  volume={476},
  pages={228-231}
}
Neurogenic transcription factors and evolutionarily conserved signalling pathways have been found to be instrumental in the formation of neurons. However, the instructive role of microRNAs (miRNAs) in neurogenesis remains unexplored. We recently discovered that miR-9* and miR-124 instruct compositional changes of SWI/SNF-like BAF chromatin-remodelling complexes, a process important for neuronal differentiation and function. Nearing mitotic exit of neural progenitors, miR-9* and miR-124 repress… CONTINUE READING
Highly Influential
This paper has highly influenced 28 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Related Discussions
This paper has been referenced on Twitter 62 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 413 extracted citations

Induced dopaminergic neurons: A new promise for Parkinson’s disease

Redox biology • 2017
View 5 Excerpts
Highly Influenced

Conversion of Fibroblasts to Neural Cells by p53 Depletion

Cell reports • 2014
View 6 Excerpts
Highly Influenced

Chemical conversion of human lung fibroblasts into neuronal cells

International journal of molecular medicine • 2018

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Similar Papers

Loading similar papers…