MicroRNA-mediated conversion of human fibroblasts to neurons

  title={MicroRNA-mediated conversion of human fibroblasts to neurons},
  author={Andrew S. Yoo and Alfred X. Sun and Li Li and Aleksandr Shcheglovitov and Thomas Portmann and Yulong Li and Chris Lee-Messer and Ricardo E Dolmetsch and Richard W. Tsien and Gerald R Crabtree},
Neurogenic transcription factors and evolutionarily conserved signalling pathways have been found to be instrumental in the formation of neurons. However, the instructive role of microRNAs (miRNAs) in neurogenesis remains unexplored. We recently discovered that miR-9* and miR-124 instruct compositional changes of SWI/SNF-like BAF chromatin-remodelling complexes, a process important for neuronal differentiation and function. Nearing mitotic exit of neural progenitors, miR-9* and miR-124 repress… CONTINUE READING
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