MicroRNA let-7i regulates dendritic cells maturation targeting interleukin-10 via the Janus kinase 1-signal transducer and activator of transcription 3 signal pathway subsequently induces prolonged cardiac allograft survival in rats.

@article{Sun2016MicroRNALR,
  title={MicroRNA let-7i regulates dendritic cells maturation targeting interleukin-10 via the Janus kinase 1-signal transducer and activator of transcription 3 signal pathway subsequently induces prolonged cardiac allograft survival in rats.},
  author={Yong Mei Sun and Xiangyuan Jin and Xianglan Liu and Maomao Zhang and Wei Liu and Zhenchao Li and Na Han and Miaoxin Tan and Di Chi and Jingyi Zhu and Bo Zhang and Bo Yu and Jian Wu},
  journal={The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation},
  year={2016},
  volume={35 3},
  pages={378-388}
}
BACKGROUND In this study, we investig1ated whether microRNA let-7i regulates dendric cell maturation targeting interleukin-10 (IL-10) via the Janus kinase 1-signal transducer and activator of transcription 3 (JAK1-STAT3) signal pathway subsequently prolongs rat cardiac allograft survival. METHODS Quantitative real-time reverse transcriptase polymerase chain reaction, enzyme linked immunosorbent assay, and dual-luciferase assay were performed to verify whether IL-10 was the target of let-7i… CONTINUE READING