MicroRNA let-7d regulates the TLX/microRNA-9 cascade to control neural cell fate and neurogenesis

@inproceedings{Zhao2013MicroRNALR,
  title={MicroRNA let-7d regulates the TLX/microRNA-9 cascade to control neural cell fate and neurogenesis},
  author={Chunnian Zhao and Guoqiang Sun and Peng Ye and Shengxiu Li and Yan-hong Shi},
  booktitle={Scientific reports},
  year={2013}
}
MicroRNAs have important functions in the nervous system through post-transcriptional regulation of neurogenesis genes. Here we show that microRNA let-7d, which has been implicated in cocaine addiction and other neurological disorders, targets the neural stem cell regulator TLX. Overexpression of let-7d in vivo reduced neural stem cell proliferation and promoted premature neuronal differentiation and migration, a phenotype similar to those induced by TLX knockdown or overexpression of its… CONTINUE READING
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