MicroRNA hsa-miR-613 targets the human LXRα gene and mediates a feedback loop of LXRα autoregulation.

@article{Ou2011MicroRNAHT,
  title={MicroRNA hsa-miR-613 targets the human LXRα gene and mediates a feedback loop of LXRα autoregulation.},
  author={Zhimin Ou and Taira Wada and Roberto Gramignoli and Song Li and Stephen C. Strom and Min Huang and Wen Xie},
  journal={Molecular endocrinology},
  year={2011},
  volume={25 4},
  pages={584-96}
}
The nuclear receptor liver X receptor (LXR) is a ligand-dependent transcription factor that plays an important role in the metabolism and homeostasis of cholesterol, lipids, bile acids, and steroid hormones. MicroRNAs (miRNAs) are recently recognized important negative regulators of gene expression. In this report, we showed that miRNA hsa-miR-613 played an important role in the autoregulation of the human LXRα gene. hsa-miR-613 targeted the endogenous LXRα through its specific miRNA response… CONTINUE READING

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