MicroRNA gets down to business

  title={MicroRNA gets down to business},
  author={George S. Mack},
  journal={Nature Biotechnology},
  • G. Mack
  • Published 1 June 2007
  • Biology
  • Nature Biotechnology
Drugs targeting microRNAs lie some way off, but diagnostics look promising and commercial interest is growing. 

Algorithms for pre-microrna classification and a GPU program for whole genome comparison

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Data Sheet : RNA Analysis

  • Biology
  • 2012
There is a strong need for a tool that facilitates widespread analysis of the expression levels of the rapidly growing list of miRNAs that have been identified so far in mice and humans.

Erratum: MicroRNA gets down to business

  • G. Mack
  • Medicine
    Nature Biotechnology
  • 2011
In the version of the article originally published, reference 8 incorrectly listed Chang, D.Z. as the first author, which should have read Tsuda, N.

Molecular and computational characterization of microRNA/target interactions

This work aims at the experimental identification of cardiac microRNA/target interactions and the computational analysis of the general concept of microRNA cooperativity.

microRNAs and Personalized Medicine: Evaluating Their Potential as Cancer Biomarkers.

Pros and cons of microRNA-based approaches that can support their exploitation as cancer biomarkers are reviewed and discussed.

Circulating miRNA in Early Diagnosis

MicroRNAs (miRNAs) are small noncoding RNAs that act as master regulators of many cellular processes. The expression of miRNAs is often deregulated in human tumors, causing the alteration of several

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  • G. Stefani
  • Biology, Medicine
    Expert opinion on biological therapy
  • 2007
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Methods employed to discover small molecule miRNA ligands, their successes thus far, and future directions for the field are focused on.

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The miRNA pathways are highly responsive to interventions of any kind, being excellent candidates for pharmacological manipulation, and new technologies for manipulating miRNAs are in need.



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MicroRNA expression profiles classify human cancers

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Identification of Virus-Encoded MicroRNAs

The small RNA profile of cells infected by Epstein-Barr virus is recorded and it is shown that EBV expresses several microRNA (miRNA) genes, which are identified viral regulators of host and/or viral gene expression.

Modulation of Hepatitis C Virus RNA Abundance by a Liver-Specific MicroRNA

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Reduced Expression of the let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival

Reduced expression of let-7 in A549 lung adenocarcinoma cell line inhibited lung cancer cell growth in vitro and represents the first report of reduced expression ofLet-7 and the potential clinical and biological effects of such a microRNA alteration.

Synthetic MicroRNA Designed to Target Glioma-Associated Antigen 1 Transcription Factor Inhibits Division and Induces Late Apoptosis in Pancreatic Tumor Cells

Gli-1 miRNAs should significantly add to the general understanding of the mechanisms of metastasis and contribute toward the design of better treatments for epithelial cancers.

Silencing of microRNAs in vivo with ‘antagomirs’

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The tumor suppressor microRNA let-7 represses the HMGA2 oncogene.

The results provide a novel example of suppression of an oncogene by a tumor-suppressive miRNA and suggest that some tumors activate the oncogen through chromosomal translocations that eliminate the onCogene's 3'UTR with the let-7 target sites.