MicroRNA gene expression deregulation in human breast cancer.


MicroRNAs (miRNAs) are a class of small noncoding RNAs that control gene expression by targeting mRNAs and triggering either translation repression or RNA degradation. Their aberrant expression may be involved in human diseases, including cancer. Indeed, miRNA aberrant expression has been previously found in human chronic lymphocytic leukemias, where miRNA signatures were associated with specific clinicobiological features. Here, we show that, compared with normal breast tissue, miRNAs are also aberrantly expressed in human breast cancer. The overall miRNA expression could clearly separate normal versus cancer tissues, with the most significantly deregulated miRNAs being mir-125b, mir-145, mir-21, and mir-155. Results were confirmed by microarray and Northern blot analyses. We could identify miRNAs whose expression was correlated with specific breast cancer biopathologic features, such as estrogen and progesterone receptor expression, tumor stage, vascular invasion, or proliferation index.

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@article{Iorio2005MicroRNAGE, title={MicroRNA gene expression deregulation in human breast cancer.}, author={Marilena V. Iorio and Manuela Ferracin and Chang-gong Liu and Angelo Veronese and Riccardo Spizzo and Silvia Sabbioni and Eros Magri and Massimo Pedriali and Muller Fabbri and Manuela Campiglio and Sylvie M{\'e}nard and Juan Pablo Palazzo and Anne L. Rosenberg and Piero Musiani and Stefano Volinia and Italo Nenci and George A. Calin and Patrizia Querzoli and Massimo Negrini and Carlo M. Croce}, journal={Cancer research}, year={2005}, volume={65 16}, pages={7065-70} }