MicroRNA expression profiling of carcinoma in situ cells of the testis.

  title={MicroRNA expression profiling of carcinoma in situ cells of the testis.},
  author={Guy Wayne Novotny and Kirstine Belling and Jesper Bertram Bramsen and John Nielsen and J Bork-Jensen and Kristian Almstrup and Si B. Sonne and J\orgen Kjems and Ewa Rajpert-De Meyts and Henrik Christian Leffers},
  journal={Endocrine-related cancer},
  volume={19 3},
Testicular germ cell tumours, seminoma (SE) and non-seminoma (NS), of young adult men develop from a precursor cell, carcinoma in situ (CIS), which resembles foetal gonocytes and retains embryonic pluripotency. We used microarrays to analyse microRNA (miRNA) expression in 12 human testis samples with CIS cells and compared it with miRNA expression profiles of normal adult testis, testis with Sertoli-cell-only that lacks germ cells, testis tumours (SE and embryonal carcinoma (EC), an… CONTINUE READING


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