MicroRNA expression profiling in classic Hodgkin lymphoma.

  title={MicroRNA expression profiling in classic Hodgkin lymphoma.},
  author={Alfons Navarro and Anna Gaya and Antonio Martinez and {\'A}lvaro Urbano-Isp{\'i}zua and Aina Pons and Olga Balagu{\'e} and Bernat Gel and Pau Abrisqueta and Armando L{\'o}pez-Guillermo and Rosa Artells and Emili Montserrat and Mariano Monz{\'o}},
  volume={111 5},
MicroRNAs (miRNAs) are negative regulators of gene expression that play an important role in hematopoiesis and tumorigenesis. We analyzed miRNA expression in classic Hodgkin lymphoma (cHL) and the influence of Epstein-Barr virus (EBV) infection on the miRNA expression profiles. The expression of 157 miRNAs in lymph nodes from 49 cHL patients and 10 reactive lymph nodes (RLNs) was analyzed by real-time polymerase chain reaction (PCR). Hierarchic clustering revealed 3 well-defined groups: nodular… CONTINUE READING
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