MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue.

@article{Roy2009MicroRNAEI,
  title={MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue.},
  author={Sashwati Roy and Savita Khanna and S. P. Akbar Hussain and Sabyasachi Biswas and Ali Azad and Cameron Rink and Surya C. Gnyawali and Shani Shilo and Gerard J Nuovo and Chandan K. Sen},
  journal={Cardiovascular research},
  year={2009},
  volume={82 1},
  pages={21-9}
}
AIMS MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the post-transcriptional level by either degradation or translational repression of a target mRNA. Encoded in the genome of most eukaryotes, miRNAs have been proposed to regulate specifically up to 90% of human genes through a process known as miRNA-guided RNA silencing. For the first time, we sought to test how myocardial ischaemia-reperfusion (IR) changes miR expression. METHODS AND RESULTS Following 2 and 7… CONTINUE READING
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