MicroRNA expression changes during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal, a product of lipid peroxidation.

@article{Pizzimenti2009MicroRNAEC,
  title={MicroRNA expression changes during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal, a product of lipid peroxidation.},
  author={Stefania Pizzimenti and Manuela Ferracin and Silvia Sabbioni and Cristina Toaldo and Piergiorgio Pettazzoni and Mario Umberto Dianzani and Massimo Negrini and Giuseppina Barrera},
  journal={Free radical biology & medicine},
  year={2009},
  volume={46 2},
  pages={282-8}
}
4-Hydroxynonenal (HNE) is one of several lipid oxidation products that may have an impact on human pathophysiology. It is an important second messenger involved in the regulation of various cellular processes and exhibits antiproliferative and differentiative properties in various tumor cell lines. The mechanisms by which HNE affects cell growth and differentiation are only partially clarified. Because microRNAs (miRNAs) have the ability to regulate several cellular processes, we hypothesized… CONTINUE READING

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