MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior.

@article{Roldo2006MicroRNAEA,
  title={MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior.},
  author={Claudia Roldo and Edoardo Missiaglia and John P. Hagan and Massimo Falconi and Paola Capelli and Samantha Bersani and George A. Calin and Stefano Volinia and Chang-gong Liu and Aldo Scarpa and Carlo M. Croce},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2006},
  volume={24 29},
  pages={4677-84}
}
PURPOSE We investigated the global microRNA expression patterns in normal pancreas, pancreatic endocrine tumors and acinar carcinomas to evaluate their involvement in transformation and malignant progression of these tumor types. MicroRNAs are small noncoding RNAs that regulate gene expression by targeting specific mRNAs for degradation or translation inhibition. Recent evidence indicates that microRNAs can contribute to tumor development and progression and may have diagnostic and prognostic… CONTINUE READING

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