MicroRNA-deficient NK cells exhibit decreased survival but enhanced function.

  title={MicroRNA-deficient NK cells exhibit decreased survival but enhanced function.},
  author={Ryan P. Sullivan and Jeffrey W. Leong and Stephanie E. Schneider and Catherine R. Keppel and Elizabeth A. Germino and Anthony R. French and Todd A Fehniger},
  journal={Journal of immunology},
  volume={188 7},
NK cells are innate immune lymphocytes important for early host defense against infectious pathogens and malignant transformation. MicroRNAs (miRNAs) are small RNA molecules that regulate a wide variety of cellular processes, typically by specific complementary targeting of the 3'UTR of mRNAs. The Dicer1 gene encodes a conserved enzyme essential for miRNA… CONTINUE READING