MicroRNA deep-sequencing reveals master regulators of follicular and papillary thyroid tumors

@article{Mankov2015MicroRNADR,
  title={MicroRNA deep-sequencing reveals master regulators of follicular and papillary thyroid tumors},
  author={Veronika Man{\vc}{\'i}kov{\'a} and Esmeralda Castelblanco and Elena Pi{\~n}eiro-Y{\'a}{\~n}ez and Javier Perales-Paton and Aguirre A. de Cubas and Luc{\'i}a Inglada-P{\'e}rez and Xavier Mat{\'i}as-Guiu and Ismael Capel and Maria Angela Bella and Enrique Lerma and Garcilaso Riesco-Eizaguirre and Pilar Santisteban and Francisco J. Maravall and D{\'i}dac Mauricio and F{\'a}tima Al-Shahrour and Mercedes Robledo},
  journal={Modern Pathology},
  year={2015},
  volume={28},
  pages={748-757}
}
MicroRNA deregulation could be a crucial event in thyroid carcinogenesis. However, current knowledge is based on studies that have used inherently biased methods. Thus, we aimed to define in an unbiased way a list of deregulated microRNAs in well-differentiated thyroid cancer in order to identify diagnostic and prognostic markers. We performed a microRNA deep-sequencing study using the largest well-differentiated thyroid tumor collection reported to date, comprising 127 molecularly… CONTINUE READING

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