MicroRNA control in the development of systemic autoimmunity

  title={MicroRNA control in the development of systemic autoimmunity},
  author={Ruozhen Hu and Ryan M O'connell},
  booktitle={Arthritis research & therapy},
Mammalian immune responses are intended to eradicate microbial pathogens and thus protect individuals from the harmful effects of such infections. However, unresolved inflammation can be devastating to the host and cause tissue damage and organ malfunction. Immune responses can even mistakenly target self-antigens and mediate autoimmune inflammation. Consequently, a variety of cellular and molecular mechanisms have evolved to control the inflammatory responses, and many of these safeguards or… CONTINUE READING
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