MicroRNA biogenesis pathways in cancer

  title={MicroRNA biogenesis pathways in cancer},
  author={Shuibin Lin and Richard Gregory},
  journal={Nature Reviews Cancer},
MicroRNAs (miRNAs) are critical regulators of gene expression. Amplification and overexpression of individual 'oncomiRs' or genetic loss of tumour suppressor miRNAs are associated with human cancer and are sufficient to drive tumorigenesis in mouse models. Furthermore, global miRNA depletion caused by genetic and epigenetic alterations in components of the miRNA biogenesis machinery is oncogenic. This, together with the recent identification of novel miRNA regulatory factors and pathways… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper


Publications citing this paper.
Showing 1-10 of 350 extracted citations

MicroRNAs in regulation of triple-negative breast cancer progression

Journal of Cancer Research and Clinical Oncology • 2018
View 5 Excerpts
Highly Influenced

Nanoformulation-based sequential combination cancer therapy.

Advanced drug delivery reviews • 2017
View 4 Excerpts
Highly Influenced

miR-34c-3p inhibits cell proliferation, migration and invasion of hepatocellular carcinoma by targeting MARCKS.

International journal of clinical and experimental pathology • 2015
View 3 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 194 references

Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors

J Wegert
Cancer Cell 27, • 2015

Similar Papers

Loading similar papers…