MicroRNA biogenesis pathways in cancer

@article{Lin2015MicroRNABP,
  title={MicroRNA biogenesis pathways in cancer},
  author={Shuibin Lin and Richard Gregory},
  journal={Nature Reviews Cancer},
  year={2015},
  volume={15},
  pages={321-333}
}
MicroRNAs (miRNAs) are critical regulators of gene expression. Amplification and overexpression of individual 'oncomiRs' or genetic loss of tumour suppressor miRNAs are associated with human cancer and are sufficient to drive tumorigenesis in mouse models. Furthermore, global miRNA depletion caused by genetic and epigenetic alterations in components of the miRNA biogenesis machinery is oncogenic. This, together with the recent identification of novel miRNA regulatory factors and pathways… CONTINUE READING

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