MicroRNA binding to the HIV-1 Gag protein inhibits Gag assembly and virus production.

  title={MicroRNA binding to the HIV-1 Gag protein inhibits Gag assembly and virus production.},
  author={Antony K. Chen and Prabuddha Sengupta and Kayoko Waki and Schuyler B. Van Engelenburg and Takahiro Ochiya and Sherimay D. Ablan and Eric O. Freed and Jennifer Lippincott-Schwartz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 26},
MicroRNAs (miRNAs) are small, 18-22 nt long, noncoding RNAs that act as potent negative gene regulators in a variety of physiological and pathological processes. To repress gene expression, miRNAs are packaged into RNA-induced silencing complexes (RISCs) that target mRNAs for degradation and/or translational repression in a sequence-specific manner. Recently, miRNAs have been shown to also interact with proteins outside RISCs, impacting cellular processes through mechanisms not involving gene… CONTINUE READING
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